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Patients with an intensive-metabolizing CYP2D6 phenotype have demonstrated higher amounts of hydromorphone during hydrocodone metabolism compared to poor metabolizers.[4] Having said that, the prevailing facts does not advocate for modified hydrocodone dosing suggestions for patients with recognized CYP2D6 polymorphisms.As a result of generous b
يجب الاهتمام وملاحظة حدوث اى نوع من الاضطرابات الهضمية وبشكل خاص النزيف المعوى المعدى.Deşi nu este necesară ajustarea dozei, se recomandă precauţie în cazul administrării la pacienţii cu insuficienţă renală.În moreover, este posibil ca sugarii născuţi de mame care